Great Lakes Equine

What is the difference between “Adequan” and “Legend”? \ by \

“Adequan” is a brand of polysulfated glycosaminoglycan (PSGAG) produced by a division of Luitpold Pharmaceuticals, Inc. The components that make up “Adequan” are chemically similar to the glycosaminoglycans in joint cartilage. It serves as an enzyme inhibitor to decrease or reverse the pathologic processes caused by trauma to the joint or degenerative joint disease. It improves joint function by reducing protein levels in the joint fluid and increasing the hyaluronic acid concentration in the synovial fluid. It is an intramuscular injection initially given more frequently for establishing the appropriate concentration in the body (loading dose), but then may be administered once a month after the loading dose has been established. The loading dose may also be repeated in 3-6 months if no maintenance dose is given.

“Legend” is an injectable solution of hyaluronate sodium produced by Bayer Health Care, LLC. Hyaluronic acid, a glycosaminoglycan, is the conjugate acid of hyaluronate sodium. Hyaluronic acid is a naturally occurring substance present in high concentrations in the joint fluid. Hyaluronic sodium decreases enzyme release and subsequent degradation of joint integrity, and decreases inflammation in the joint. “Legend” is an intravenous injection initially given more frequently for establishing the appropriate concentration in the body (loading dose), but then may be administered once a month after the loading dose has been established.

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